Andrea Pazienza debuted in 1977 on the magazine Alteralter with his first comic story, The Extraordinary Adventures of Pentothal, the surrealistic and psychedelic story of an alter ego named after the sedative Penthothal. He subsequently published several short stories on Cannibale, Il Male, and Frigidaire, of which he was one of the founders. Pazienza developed a personal body of work, alternating between playful comic cartooning—at times politically charged–and much more elaborate, dark, disturbing graphic novels, often dealing with drugs and wanton violence, with a scattering of black humor throughout. In 1980, he created the character Zanardi and collaborated with the magazines Corto Maltese and Comic Art, while also producing movie and theatre posters, scene designs, record covers, and advertising material. He was extremely prolific through the 1980s, penning hundreds of single-panel cartoons as well as longer, intricate stories. Pompeo, his last graphic novel, depicts the gradual downfall of a heroin addict (a largely autobiographical character), is generally considered his masterwork. He died of heroin overdose in 1988, at the age of 32.