Brought up Jewish, Elizabeth Wurtzel's parents divorced when she was young. As described in Prozac Nation, Wurtzel's depression began at the ages of ten to twelve. She attended Ramaz for high school and was described as an overachiever by her teachers, who expected her to become a nationally famous writer. While an undergraduate at Harvard College, she wrote for The Harvard Crimson and the Dallas Morning News. Wurtzel also received the 1986 Rolling Stone Magazine College Journalism Award. Following her graduation, Wurtzel moved to Greenwich Village in New York City and found work as pop music critic for The New Yorker and New York Magazine.
Elizabeth Wurtzel died on January 7, 2020, from complications due to cancer. She was fifty-two at the time of her death.