Barthelme's works are known for their focus on the landscape of the New South. Along with his reputation as a minimalist, together with writers Raymond Carver, Ann Beattie, Amy Hempel, and Mary Robison, Barthelme's work has also been described by terms such as "dirty realism" and "K-mart realism."He published his first short story in The New Yorker,and has claimed that a rotisserie chicken helped him understand that he needed to write about ordinary people.He has moved away from the postmodern stylings of his older brother, Donald Barthelme, though his brother's influence can be seen in his earliest works, Rangoon and War and War.
Barthelme was thirty-three year editor and visionary of Mississippi Review, known for recognizing and publishing once new talents such as Larry Brown, Curtis Sittenfeld, and Amy Hempel early in their careers.