Fritz Richard Stern was born in Breslau, Silesia, to prominent parents: his father, Rudolf Stern, a physician and medical researcher, and his mother, Käthe Brieger Stern, a noted theorist and reformer in the education of young children. After converting from Judaism to Lutheran Protestantism in the 1890s, his family emigrated to the United States in 1938, forced to leave by the virulently anti-Jewish policies of Adolf Hitler's National Socialist government and increasing violence against all Germans of Jewish ancestry. The family settled in New York City where Stern attended Columbia University from which he received his bachelors, masters and PhD. From 1953 to 1997, he was a professor at Columbia, obtaining the eminent Seth Low Chair before attaining the rank of University Professor.
Much of Stern's work tracks the development of the rise of National Socialism in Germany, tracing that the origins of Nazism back to the 19th century völkische movement. In Stern's opinion, the virulently anti-Semitic völkische movement was the result of the "politics of cultural despair" experienced by German intellectuals who were unable to come to grips with modernity. He rejects the Sonderweg interpretation of German history which considers Germany to have followed a unique course from aristocracy into democracy distinct from other European countries. In the 1990s, Stern was a leading critic of the controversial American author Daniel Goldhagen, whose book Hitler's Willing Executioners he denounced as unscholarly and full of Germanophobia.
Another major area of research for Stern has been the history of the Jewish community in Germany and how Jewish and German cultures have influenced each other -- what Stern has often called the "Jewish-German symbiosis," the best examplar of which was Albert Einstein.