Harry Eugene Crews was born during the Great Depression to sharecroppers in Bacon County, Georgia. His father died when he was an infant and his mother quickly remarried. His mother later moved her sons to Jacksonville, Florida. Crews is twice divorced and is the father of two sons. His eldest son drowned in 1964.
Crews served in the Korean War and, following the war, enrolled at the University of Florida under the G.I. Bill. After two years of school, Crews set out on an extended road trip. He returned to the University of Florida in 1958. Later, after graduating from the master's program, Crews was denied entrance to the graduate program for Creative Writing. He moved to Ft. Lauderdale, Florida, where he taught English at Broward Community College. In 1968, Crews' first novel, The Gospel Singer, was published. Crews returned to the University of Florida as an English faculty member.
In spring of 1997, Crews retired from UF to devote himself fully to writing. Crews published continuously since his first novel, on average of one novel per year. He died in 2012, at the age of 78.