Harry Mathews was an American author of various novels, volumes of poetry and short fiction, and essays.
Together with John Ashbery, James Schuyler, and Kenneth Koch, Mathews founded and edited the short-lived but influential literary journal Locus Solus (named after a novel by Raymond Roussel, one of Mathews's chief early influences) from 1961 to 1962.
Harry Mathews was the first American chosen for membership in the French literary society known as the Oulipo, which is dedicated to exploring new possibilities in literature, in particular through the use of various constraints and algorithms. The late French writer Georges Perec, likewise a member, was a good friend, and the two translated some of each other's writings. Mathews considers many of his works to be Oulipian in nature, but even before he encountered the society he was working in a parallel direction.
Mathews was married to the writer Marie Chaix and divided his time between Paris, Key West, and New York.