Jacques Monod
Jacques Lucien Monod (9 February 1910 – 31 May 1976) was a French biologist who was awarded a Nobel Prize in Physiology or Medicine in 1965, sharing it with François Jacob and Andre Lwoff "for their discoveries concerning genetic control of enzyme and virus synthesis".
Monod (along with François Jacob) is famous for his work on the E. coli lac operon, which encodes proteins necessary for the transport and breakdown of the sugar lactose (lac). From their own work and the work of others, he and Jacob came up with a model for how the levels of some proteins in a cell are controlled. In their model, the manufacture of proteins, such as the ones encoded within the lac (lactose) operon, is prevented when a repressor, encoded by a regulatory gene, binds to its operator, a specific site on the DNA next to the genes encoding the proteins. It is now known that repressor bound to the operator physically blocks RNA polymerase from binding to the promoter, the site where transcription of the adjacent genes begins.
Study of the control of expression of genes in the lac operon provided the first example of a transcriptional regulation system. He also suggested the existence of mRNA molecules that link the information encoded in DNA and proteins. Monod is widely regarded as one of the founders of molecular biology. Monod's interest in the lac operon originated from his doctoral dissertation, for which he studied the growth of bacteria in culture media containing two sugars.
Monod was also awarded several other honours and distinctions, among them the Légion d'honneur.
“Modern societies accepted the treasures and the power offered them by science. But they have not accepted - they have scarcely even heard - its profounder message: the defining of a new and unique source of truth, and the demand for a thorough revision of ethical premises, for a complete break with the animist tradition, the definitive abandonment of the 'old covenant', the necessity of forging a new one. Armed with all the powers, enjoying all the riches they owe to science, our societies are still trying to live by and to teach systems of values already blasted at the root by science itself.”
“Among all the occurrences possible in the universe the a priori probability of any particular one of them verges upon zero. Yet the universe exists; particular events must take place in it, the probability of which (before the event) was infinitesimal. At the present time we have no legitimate grounds for either asserting or denying that life got off to but a single start on earth, and that, as a consequence, before it appeared its chances of occurring were next to nil. ... Destiny is written concurrently with the event, not prior to it... The universe was not pregnant with life nor the biosphere with man. Our number came up in the Monte Carlo game. Is it surprising that, like the person who has just made a million at the casino, we should feel strange and a little unreal?”
“A curious aspect of the theory of evolution is that everybody thinks he understands it.”
“What is true for E. coli is also true for the elephant.”
“Everything comes from experience; yet not from actual experience, reiterated by each individual with each generation, but instead from experience accumulated by the entire ancestry of the species in the course of its evolution.”
“The ancient covenant is in pieces; man knows at last that he is alone in the universe's unfeeling immensity, out of which he emerged only by chance. His destiny is nowhere spelled out, nor is his duty. The kingdom above or the darkness below: it is for him to choose.”