Jim Harrison was born in Grayling, Michigan, to Winfield Sprague Harrison, a county agricultural agent, and Norma Olivia (Wahlgren) Harrison, both avid readers. He married Linda King in 1959 with whom he has two daughters.
His awards include National Academy of Arts grants (1967, 68, 69), a Guggenheim Fellowship (1969-70), the Spirit of the West Award from the Mountain & Plains Booksellers Association, and election to the American Academy of Arts and Sciences (2007).
Much of Harrison's writing depicts sparsely populated regions of North America with many stories set in places such as Nebraska's Sand Hills, Michigan's Upper Peninsula, Montana's mountains, and along the Arizona-Mexico border.