A longterm resident of Puerto Rico from 1920 until her death, she was an activist on issues of women's suffrage and equal rights in Latin America. Lee worked for more than two decades in cultural affairs for the United States State Department, promoting artistic and literature exchanges between Latin America and the US, as well as other countries.
She is remembered for her poetry, but also co-authored five detective novels with Maurice Guinness, an American Shell Oil executive, under the pen name Newton Gayle.