Wolfgang Herrndorf studied painting at the Academy of Fine Arts, Nuremberg. After graduating, he moved to Berlin, where he worked as a magazine illustrator and posted frequently on the Internet forum Wir höflichen Paparazzi (We Polite Paparazzi). In 2001, Herrndorf joined the art and writing collective Zentrale Intelligenz Agentur, eventually contributing to their blog, Riesenmaschine (Giant Machine).
He published his first novel, In Plüschgewittern (Storm of Plush), in 2002. This was followed by a collection of short stories, Diesseits des Van-Allen-Gürtels (This Side of the Van Allen Belt, 2007), which received the Ingeborg Bachmann Prize Audience Award.
In early 2010, he was diagnosed with a brain tumor; his novel Tschick (Why We Took the Car) was published just months later and would eventually be translated into twenty-four languages. Sand was released in 2011; it was short-listed for the German Book Prize and won the Leipzig Book Fair Prize.
Herrndorf committed suicide in the summer of 2013. His posts on Arbeit und Struktur (Work and Structure), the blog he started after receiving his cancer diagnosis, have been published as a book of the same name. An unfinished sequel to Tschick, Bilder einer großen Liebe (Pictures of Your True Love), was released in 2014.