40 Uplifting Depression Quotes

Feeling weighed down by the challenges of daily life can be overwhelming, especially when battling feelings of depression. Sometimes, a few encouraging words can provide the spark needed to ignite hope and resilience. We've gathered a curated collection of the top 40 uplifting quotes designed to offer comfort and inspiration during tough times. Whether you're seeking solace or looking to uplift someone you care about, these powerful quotes aim to remind you that brighter days are always ahead. Dive into our selection and let these words of wisdom illuminate your path to a more hopeful and optimistic mindset.

1. “I feel like a defective model, like I came off the assembly line flat-out fucked and my parents should have taken me back for repairs before the warranty ran out.” - Elizabeth Wurtzel

2. “The pupil dilates in darkness and in the end finds light, just as the soul dilates in misfortune and in the end finds God.” - Victor Hugo

3. “That is all I want in life: for this pain to seem purposeful.” - Elizabeth Wurtzel

4. “And I felt like my heart had been so thoroughly and irreparably broken that there could be no real joy again, that at best there might eventually be a little contentment. Everyone wanted me to get help and rejoin life, pick up the pieces and move on, and I tried to, I wanted to, but I just had to lie in the mud with my arms wrapped around myself, eyes closed, grieving, until I didn’t have to anymore.” - Anne Lamott

5. “Noble deeds and hot baths are the best cures for depression.” - Dodie Smith

6. “People with family histories of alcoholism tend to have lower levels of endorphins- the endogenous morphine that is responsible for many of our pleasure responses- than do people genetically disinclined to alcoholism. Alcohol will slightly raise the endorphin level of people without the genetic basis for alcoholism; it will dramatically raise the endorphin level of people with that genetic basis. Specialists spend a lot of time formulating exotic hypotheses to account for substance abuse. Most experts point out, strong motivations for avoiding drugs; but there are also strong motivations for taking them. People who claim not to understand why anyone would get addicted to drugs are usually people who haven't tried them or who are genetically fairly invulnerable to them.” - Andrew Solomon

7. “She wondered that hope was so much harder then despair.” - Patricia Briggs

8. “In those pamphlets that they give at mental health centers where they list the ten or so symptoms that would indicate a clinical depression, 'suicide threats' or even simple 'talk of suicide' is considered cause for concern. I guess the point is that what's just talk one day may become a real activity the next. So perhaps after years of walking around with these germinal feelings, these raw thoughts, these scattered moments of saying I wish I were dead, eventually I too, sooner or later, would succumb to the death urge. In the meantime, I could withdraw to my room, could hide and sleep as if I were dead.” - Elizabeth Wurtzel

9. “When psychologists Catherine Caldwell-Harris and Ayse Ayçiçegi compared U.S. and Turkish samples, they found that having "an orientation inconsistent with societal values" is a risk factor for poor mental health. The findings support what the researchers call the personality-culture clash hypothesis: "Psychological adjustment depends on the degree of match between personality and the values of surrounding society." To the extent that introverts feel the need to explain, apologize, or feel guilty about what works best for them, they feel alienated not only from society but from themselves.” - Laurie Helgoe

10. “Whomsoever controls the volume of money in any country is absolute master of all industry and commerce and when you realize that the entire system is very easily controlled, one way or another, by a few powerful men at the top, you will not have to be told how periods of inflation and depression originate.” - James Garfield

11. “Grief is depression in proportion to circumstance; depression is grief out of proportion to circumstance.” - Andrew Solomon

12. “Its so hard to talk when you want to kill yourself. That's above and beyond everything else, and it's not a mental complaint-it's a physical thing, like it's physically hard to open your mouth and make the words come out. They don't come out smooth and in conjunction with your brain the way normal people's words do; they come out in chunks as if from a crushed-ice dispenser; you stumble on them as they gather behind your lower lip. So you just keep quiet.” - Ned Vizzini

13. “...Sometimes they open it up like a package in the presence of a person they can talk to,' she said. 'Someone they can trust.' She held out her hands. 'Any person who is carrying a lot of sadness,' she said, 'needs to be able to rest sometimes, and to put it down.” - Julia Schumacher

14. “I just want to sleep. A coma would be nice. Or amnesia. Anything, just to get rid of this, these thoughts, whispers in my mind. Did he rape my head, too?” - Laurie Halse Anderson

15. “Almost everyone is overconfident--except the people who are depressed, and they tend to be realists.” - Joseph T. Hallinan

16. “Depression, we are told over and over again, is a brain disease, a chemical imbalance that can be adjusted by antidepressant medication. In an informational brochure issued to inform the public about depression, the US National Institute for Mental Health tells people that 'depressive illnesses are disorders of the brain' and adds that 'important neurotransmitters - chemicals that brain cells use to communicate - appear to be out of balance'. This view is so widespread that it was even proffered by the editors of PLoS [Public Library of Science] Medicine in their summary that accompanied our article. 'Depression,' they wrote, 'is a serious medical illness caused by imbalances in the brain chemicals that regulate mood', and they went on to say that antidepressants are supposed to work by correcting these imbalances.The editors wrote their comment on chemical imbalances as if it were an established fact, and this is also how it is presented by drug companies. Actually, it is not. Instead, even its proponents have to admit that it is a controversial hypothesis that has not yet been proven. Not only is the chemical-imbalance hypothesis unproven, but I will argue that it is about as close as a theory gets in science to being dis-proven by the evidence.” - Irving Kirsch

17. “Like antidepressants, a substantial part of the benefit of psychotherapy depends on a placebo effect, or as Moerman calls it, the meaning response. At least part of the improvement that is produced by these treatments is due to the relationship between the therapist and the client and to the client's expectancy of getting better. That is a problem for antidepressant treatment. It is a problem because drugs are supposed to work because of their chemistry, not because of the psychological factors. But it is not a problem for psychotherapy. Psychotherapists are trained to provide a warm and caring environment in which therapeutic change can take place. Their intention is to replace the hopelessness of depression with a sense of hope and faith in the future. These tasks are part of the essence of psychotherapy. The fact that psychotherapy can mobilize the meaning response - and that it can do so without deception - is one of its strengths, no one of its weaknesses. Because hopelessness is a fundamental characteristic of depression, instilling hope is a specific treatment for it it. Invoking the meaning response is essential for the effective treatment of depression, and the best treatments are those that can do this most effectively and that can do without deception.” - Irving Kirsch

18. “For people who are depressed, and especially for those who do not receive enough benefit from medication of for whom the side effects of antidepressants are troubling, the fact that placebos can duplicate much of the effects of antidepressants should be taken as good news. It means that there are other ways of alleviating depression. As we have seen, treatments like psychotherapy and physical exercise are at least as effective as antidepressant drugs and more effective than placebos. In particular, CBT has been shown to lower the risk of relapsing into depression for years after treatment has ended, making it particularly cost effective.” - Irving Kirsch

19. “Nothing is quite as depressing as depression.” - Claire Weekes

20. “On Prozac, Sisyphus might well push the boulder back up the mountain with more enthusiasm and creativity. I do not want to deny the benefits of psychoactive medication. I just want to point out that Sisyphus is not a patient with a mental health problem. To see him as a patient with a mental health problem is to ignore certain larger aspects of his predicament connected to boulders, mountains, and eternity.” - Carl Elliott

21. “Depression is not madness, it's just depression, the loser version, the low-energy response to bad stuff that happens in your life. When you're depressed, you think you're the only one to have ever tasted this kind of hurt. And that lonely self-regard brings with it its own painful pleasure.” - Ana Menéndez

22. “Be happy -- if you're not even happy, what's so good about surviving?” - Tom Stoppard

23. “Even extreme grief may ultimately ventitself in violence--but more generally takes the form of apathy” - Joseph Conrad

24. “Depression is anger turned inward.” - Sapphire

25. “When I was young I was depressed all the time. But suicide no longer seemed a possibility in my life. At my age there was very little left to kill. It was good to be old, no matter what they said. It was reasonable that a man had to be at least 50 years old before he could write with anything like clarity.” - Charles Bukowski

26. “When I need some striking inspiration about deep depression for my new painting, I just need to go to check my bank account...” - Hiroko Sakai

27. “Time had not faded my memories (as I had prayed to God it might), nor had it healed my wounds as it is said always to do. I began each day with the hope that the next day would be better, my recollections a little less pointed, but I would awake to the same pain, as if a black lamp were burning eternally inside me, radiating darkness.” - Orhan Pamuk

28. “Like if Leonardo from the Teenage Mutant Ninja Turtles started being all bummed out about everything. How were we going to kick arse if our Leonardo was wearing a black eye-band instead of a blue one?” - Dougie Poynter

29. “There's a boy whose affection I am determined to hunt down and kill. It used to be material objects I felt I needed to be happy. It would make me feel stable if I had him. If I had someone like him, it would prove that I'm stable, and then I wouldn't have to do the work to get there. I am constantly looking for ways to cede control of my worries to someone, anyone.” - Emma Forrest

30. “What people don't understand when you've already been a suicide and pulled through is that after the sadness comes fear: Where is my mind going with this? I don't want to die. I do not want to die. When you don't have so much control over your own thoughts, over the myriad voices in your head, you don't know where they could go.” - Emma Forrest

31. “The sadness ― the general sadness that squats and pees inside my brain ― isn't over. It never will be. I know how best to chase it away, though. It usually works. Sometimes it doesn't. But I pray and say, fuck it, then. I choose this. It chooses me. I choose it back.” - Emma Forrest

32. “Life is short enough, there is nothing worth here to take your life, and those things we do gain can never be taken to our grave.” - Anthony Liccione

33. “Some people can’t keep fighting. Some people want to escape. Some people are not ready—are not able—to find a way to deal with what’s in front of them. Sometimes there’s no one to help them. Sometimes they don’t know how to ask for help. Sometimes it feels like there’s no choice but to end it. No other way out. And sometimes it’s impossible to see past that.” - Sarah Fine

34. “They thought depression was like bieng 'depressed'. They thought it was like being in a bad mood, only worse. Therefore, they tried to get him to snap out of it.” - Jeffrey Eugenides

35. “I want to escape from myself. For when I do start up and stare myself seedily in the face, as happens to be my case at present, my blankness is inconceivable--indescribable--my misery amazing.” - Charles Dickens

36. “Depression makes me stronger” - shayamalan

37. “You cannot move forward if you are always thinking backwards” - Bathsheba Dailey

38. “The next morning I told Mom I couldn't go to school again. She asked what was wrong. I told her, “The same thing that’s always wrong.” “You’re sick?” “I'm sad.” “About Dad?” “About everything.” She sat down on the bed next to me, even though I knew she was in a hurry. “What's everything?” I started counting on my fingers: “The meat and dairy products in our refrigerator, fistfights, car accidents, Larry–” “Who's Larry?” “The homeless guy in front of the Museum of Natural History who always says ‘I promise it’s for food’ after he asks for money.” She turned around and I zipped her dress while I kept counting. “How you don’t know who Larry is, even though you probably see him all the time, how Buckminster just sleeps and eats and goes to the bathroom and has no ‘raison d’etre’, the short ugly guy with no neck who takes tickets at the IMAX theater, how the sun is going to explode one day, how every birthday I always get at least one thing I already have, poor people who get fat because they eat junk food because it’s cheaper…” That was when I ran out of fingers, but my list was just getting started, and I wanted it to be long, because I knew she wouldn't leave while I was still going. “…domesticated animals, how I have a domesticated animal, nightmares, Microsoft Windows, old people who sit around all day because no one remembers to spend time with them and they’re embarrassed to ask people to spend time with them, secrets, dial phones, how Chinese waitresses smile even when there’s nothing funny or happy, and also how Chinese people own Mexican restaurants but Mexican people never own Chinese restaurants, mirrors, tape decks, my unpopularity in school, Grandma’s coupons, storage facilities, people who don’t know what the Internet is, bad handwriting, beautiful songs, how there won’t be humans in fifty years–” “Who said there won't be humans in fifty years?” I asked her, “Are you an optimist or a pessimist?” She looked at her watch and said, “I'm optimistic.” “Then I have some bed news for you, because humans are going to destroy each other as soon as it becomes easy enough to, which will be very soon.” “Why do beautiful songs make you sad?” “Because they aren't true.” “Never?” “Nothing is beautiful and true.” - Jonathan Safran Foer

39. “Author describes that a failed sea captain, "vacillated miserably between self-recrimination and defensiveness.” - Joseph Wheelan

40. “A dog's spirit dies hard.” - Mikhail Bulgakov