“Geography is the key, the crucial accident of birth. A piece of protein could be a snail, a sea lion, or a systems analyst, but it had to start somewhere. This is not science; it is merely metaphor. And the landscape in which the protein "starts" shapes its end as surely as bowls shape water.”

“In nature, improbabilities are the one stock in trade. The whole creation is one lunatic fringe. If creation had been left up to me, I'm sure I wouldn't have had the imagination or courage to do more than shape a single, reasonably sized atom, smooth as a snowball, and let it go at that.”

“There was only silence. It was the silence of matter caught in the act and embarrassed. There were no cells moving, and yet there were cells. I could see the shape of the land, how it lay holding silence. Its poise and its stillness were unendurable, like the ring of the silence you hear in your skull when you're little and notice you're living the ring which resumes later in life when you're sick.”

“life by its mere appalling length is a feat of endurance for which you haven't the strength.”

“You can, in short, lead the life of the mind, which is, despite some appalling frustrations, the happiest life on earth. And one day, in the thick of this, approaching some partial vision, you will (I swear) find yourself on the receiving end of - of all things - an "idea for a story," and you will, God save you, start thinking about writing some fiction of your own. Then you will understand, in what I fancy might be a blinding flash, that all this passionate thinking is what fiction is about, that all those other fiction writers started as you did, and are laborers in the same vineyard.”

“A work in progress quickly becomes feral. It reverts to a wild state overnight. It is barely domesticated, a mustang on which you one day fastened a halter, but which now you cannot catch. It is a lion you cage in your study. As the work grows, it gets harder to control; it is a lion growing in strength. You must visit it every day and reassert your mastery over it. If you skip a day, you are, quite rightly, afraid to open the door to its room. You enter its room with bravura, holding a chair at the thing and shouting, "Simba!”

“I had been chipping at the world idly, and had by accident uncovered vast and labyrinthine further worlds within it.”