“Life is wonderful and strange...and it’s also absolutely mundane and tiresome. It’s hilarious and it’s deadening. It’s a big, screwed-up morass of beauty and change and fear and all our lives we oscillate between awe and tedium. I think stories are the place to explore that inherent weirdness; that movement from the fantastic to the prosaic that is life....What interests me—and interests me totally—is how we as living human beings can balance the brief, warm, intensely complicated fingersnap of our lives against the colossal, indifferent, and desolate scales of the universe. Earth is four-and-a-half billion years old. Rocks in your backyard are moving if you could only stand still enough to watch. You get hernias because, eons ago, you used to be a fish. So how in the world are we supposed to measure our lives—which involve things like opening birthday cards, stepping on our kids’ LEGOs, and buying toilet paper at Safeway—against the absolutely incomprehensible vastness of the universe? How? We stare into the fire. We turn to friends, bartenders, lovers, priests, drug-dealers, painters, writers. Isn’t that why we seek each other out, why people go to churches and temples, why we read books? So that we can find out if life occasionally sets other people trembling, too?”

“Because in the end, the measure of a well-lived life is not titles or riches. It’s not even measured by the people we please, especially at the cost of our own souls. No, the true measure of a well-lived life is how well we love…and how well we are loved in return.”

“To exist in this vast universe for a speck of time is the great gift of life. Our tiny sliver of time is our gift of life. It is our only life. The universe will go on, indifferent to our brief existence, but while we are here we touch not just part of that vastness, but also the lives around us. Life is the gift each of us has been given. Each life is our own and no one else's. It is precious beyond all counting. It is the greatest value we can have. Cherish it for what it truly is..... Your life is yours alone. Rise up and live it.”

“I don’t find our relative insignificance disheartening at all: The main thing it tells me is that in a culture that worships celebrity and the purportedly extraordinary, ALL people are ordinary people. ALL people have the same responsibilities to themselves and to each other. Maybe the universe cares nothing for us, but WE care about each other. And most encouragingly, we care not just for our friends or family but for the whole enterprise of life—we care about strangers and about humpback whales and, most beautifully of all, we care about the dead. We try with our lives to honor theirs. That’s how we make our lives meaningful, and how we make their lives meaningful, too.”

“Whether we’re the largest, smallest, most or least significant thing in the universe makes for a marvelous late-night discussion. It’s not relevant to how we live in the here and now. We need to look around, take measure of ourselves, and decide what we can do and how much of it we do to improve our lives and the lives of as many others as we can reach.”

“We read novels because we need stories; we crave them; we can’t live without telling them and hearing them. Stories are how we make sense of our lives and of the world. When we’re distressed and go to therapy, our therapist’s job is to help us tell our story. Life doesn’t come with plots; it’s messy and chaotic; life is one damn, inexplicable thing after another. And we can’t have that. We insist on meaning. And so we tell stories so that our lives make sense.”