“Of all ruins, that of a noble mind is the most deplorable.- The Adventure of the Dying Detective”

“There are no crimes and no criminals in these days. What is the use of having brains in our profession? I know well that I have it in me to make my name famous. No man lives or has ever lived who has brought the same amount of study and of natural talent to the detection of crime which I have done. And what is the result? There is no crime to detect, or, at most, some bungling villainy with a motive so transparent that even a Scotland Yard official can see through it.”

“I shall never do that,' I answered; 'you have brought detection as near an exact science as it ever will be brought in this world.”

“They say that genius is an infinite capacity for taking pains," he remarked with a smile. "It's a very bad definition, but it does apply to detective work.”

“No ghosts need apply. - Sherlock Holmes: The Adventure of the Sussex Vampire”

“Life is infinitely stranger than anything which the mind of man could invent. We would not dare to conceive the things which are really mere commonplaces of existence. If we could fly out of that window hand in hand, hover over this great city, gently remove the roofs, and and peep in at the queer things which are going on, the strange coincidences, the plannings, the cross-purposes, the wonderful chains of events, working through generations, and leading to the most outre results, it would make all fiction with its conventionalities and foreseen conclusions most stale and unprofitable.”

“My mind," he said, "rebels at stagnation. Give me problems, give me work, give me the most abstruse cryptogram or the most intricate analysis, and I am in my own proper atmosphere. I can dispense then with artificial stimulants. But I abhor the dull routine of existence. I crave for mental exaltation. That is why I have chosen my own particular profession, or rather created it, for I am the only one in the world.”