“I had hoped for a pinch of metaphor.”

“At some point in my life I'd honestly hoped love would rescue me from the cold, drafty castle I lived in. But at another point, much earlier I think, I'd quietly begun to hope for nothing at all in the way of love, so as not to be disappointed. It works. It gets to be a habit.”

“One of the very first things I figured out about life...is that it's better to be a hopeful person than a cynical, grumpy one, because you have to live in the same world either way, and if you're hopeful, you have more fun.”

“the unbearable persistence of hope”

“I keep hoping some guy with 'Ron' or 'Andy' stitched on his pocket and a gas pump in his hand will step up and tell me where I'm headed.”

“The seat of human emotion should be the liver," Doc Homer said. "That would be an appropriate metaphor: we don't hold love in our hearts, we hold it in our livers."I understood exactly. Once in ER I saw a woman who'd been stabbed everywhere, most severely in the liver. It's an organ with the consistency of layer upon layer of wet Kleenex. Every attempt at repair just opens new holes that tear and bleed. You try to close the wound with fresh wounds, and you try and you try and you don't give up until there's nothing left.”

“The very least you can do in your life is figure out what you hope for. And the most you can do is live inside that hope. Not admire it from a distance but live right in it, under its roof.”