“Two large trials of antioxidants were set up after Peto’s paper (which rather gives the lie to nutritionists’ claims that vitamins are never studied because they cannot be patented: in fact there have been a great many such trials, although the food supplement industry, estimated by one report to be worth over $50 billion globally, rarely deigns to fund them). One was in Finland, where 30,000 participants at high risk of lung cancer were recruited, and randomised to receive either ß-carotene, vitamin E, or both, or neither. Not only were there more lung cancers among the people receiving the supposedly protective ß-carotene supplements, compared with placebo, but this vitamin group also had more deaths overall, from both lung cancer and heart disease. The results of the other trial were almost worse. It was called the ‘Carotene and Retinol Efficacy Trial’, or ‘CARET’, in honour of the high p-carotene content of carrots. It’s interesting to note, while we’re here, that carrots were the source of one of the great disinformation coups of World War II, when the Germans couldn’t understand how our pilots could see their planes coming from huge distances, even in the dark. To stop them trying to work out if we’d invented anything clever like radar (which we had), the British instead started an elaborate and entirely made-up nutritionist rumour. Carotenes in carrots, they explained, are transported to the eye and converted to retinal, which is the molecule that detects light in the eye (this is basically true, and is a plausible mechanism, like those we’ve already dealt with): so, went the story, doubtless with much chortling behind their excellent RAF moustaches, we have been feeding our chaps huge plates of carrots, to jolly good effect. Anyway. Two groups of people at high risk of lung cancer were studied: smokers, and people who had been exposed to asbestos at work. Half were given 3-carotene and vitamin A, while the other half got placebo. Eighteen thousand participants were due to be recruited throughout its course, and the intention was that they would be followed up for an average of six years; but in fact the trial was terminated early, because it was considered unethical to continue it. Why? The people having the antioxidant tablets were 46 per cent more likely to die from lung cancer, and 17 per cent more likely to die of any cause,* than the people taking placebo pills. This is not news, hot off the presses: it happened well over a decade ago.”

“So should we ban or restrict synthetic chemicals until we have a full understanding of their effects? This attractively simple idea is a lot more complicated than it appears. If pesticides were banned, agricultural yields would decline, fruits and vegetables would get more expensive and people would buy and eat fewer of them. But cancer scientists believe that fruits and vegetables can reduce the risk of cancer if we eat enough of them, which most people do not do even now. And so banning pesticides in order to reduce exposure to carcinogens could potentially result in more people getting cancer.”

“Cats are true carnivores. While you may choose a vegetarian lifestyle, don't assume it's healthier for your cat also. Cats aren't able to convert beta-carotene into vitamin A the way we can. They must get vitamin A from animal tissue (called preformed A). Cats are also unable to convert linoleic acid (an essential fatty acid) to arachidonic acid the way dogs can so they must get preformed arachidonic acid from its only source—animal tissue.”

“When it comes to dead bodies in current psychotropic trials, there are a greater number of them in the active treatment groups than in the placebo groups. This is quite different from what happens in penicillin trials or trials of drugs that really work. -David Healy”

“(What Jim had seen tallied with studies conducted after the Second WorldWar by the military historian General S.L.A. Marshall. He interviewed thousands of American infantrymen and concluded that only 15-20 per cent of them had actually shot to kill. The rest had fired high or not fired at all, busying themselves however else they could. And 98 per cent of the soldiers who did shoot to kill were later found to have been deeply traumatized by their actions. The other 2 per cent were diagnosed as ‘aggressive psychopathic personalities’, who basically didn’t mind killing people under any circumstances, at home or abroad.The conclusion—in the words of Lieutenant Colonel Dave Grossman of the Killology Research Group—was: ‘there is something about continuous, inescapable combat which will drive 98 per cent of all men insane, and the other 2 per cent were crazy when they got there’.)”

“Both vitamin pills and vegetables are loaded with essential nutrients, but not in the same combinations. Spinach is a good source of both vitamin C and iron. As it happens, vitamin C boosts iron absorption, allowing the body to take in more of it than if the mineral were introduced alone. When I first started studying nutrition, I became fascinated with these coincidences, realizing of course they're not coincidences. Human bodies and their complex digestive chemistry evolved over millenia in response to all the different foods--mostly plants--they raised or gathered from the land surrounding them. They may have died young from snakebite or blunt trauma, but they did not have diet-related illnesses like heart disease and Type II diabetes that are prevalent in our society now, even in some young adults and children. [from an entry by Barbara Kingsolver's daughter Camille]”