“Trying and getting hurt can't possibly be worse for you than being... stuck.”

“Doing worse with more knowledge means you are doing something very wrong.”

“Not every change is an improvement but every improvement is a change; you can't do anything BETTER unless you can manage to do it DIFFERENTLY, you've got to let yourself do better than other people!”

“People go funny in the head when talking about politics. The evolutionary reasons for this are so obvious as to be worth belaboring: In the ancestral environment, politics was a matter of life and death. And sex, and wealth, and allies, and reputation... When, today, you get into an argument about whether "we" ought to raise the minimum wage, you're executing adaptations for an ancestral environment where being on the wrong side of the argument could get you killed. Being on the right side of the argument could let you kill your hated rival![...]Politics is an extension of war by other means. Arguments are soldiers. Once you know which side you're on, you must support all arguments of that side, and attack all arguments that appear to favor the enemy side; otherwise it's like stabbing your soldiers in the back—providing aid and comfort to the enemy. People who would be level-headed about evenhandedly weighing all sides of an issue in their professional life as scientists, can suddenly turn into slogan-chanting zombies when there's a Blue or Green position on an issue.”

“- With respect, Professor McGonagall, I'm not quite sure you understand what I'm trying to do here.- With respect, Mr. Potter, I'm quite sure I don't. Unless - this is a guess, mind - you're trying to take over the world?- No! I mean yes - well, NO!- I think i should perhaps be alarmed that you have trouble answering the question.”

“One of chief pieces of advice I give to aspiring rationalists is "Don't try to be clever." And, "Listen to those quiet, nagging doubts." If you don't know, you don't know what you don't know, you don't know how much you don't know, and you don't know how much you needed to know.”

“The glass display cases had shown rock-throwers crafted by the Australian aborigines - like giant wooden shoehorns, they'd looked, but smoothed and carved and ornamented with the most painstaking care. In the 40,000 years since anatomically modern humans had migrated to Australia from Asia, nobody had invented the bow-and-arrow. It really made you appreciate how non-obvious was the idea of Progress. Why would you even think of Invention as something important, if all your history's heroic tales were of great warriors and defenders instead of Thomas Edison? How could anyone possibly have suspected, while carving a rock-thrower with painstaking care, that someday human beings would invent rocket ships and nuclear energy?”