“Infectious disease is one of the great tragedies of living things - the struggle for existence between two different forms of life... Incessantly, the pitiless war goes on, without quarter or armistice - a nationalism of species against species.”

“Swords, Lances, arrows, machine guns, and even high explosives have had far less power over the fates of nations than the typhus louse, the plague flea, and the yellow-fever mosquito. Civilizations have retreated from the plasmodium of malaria, and armies have crumbled into rabbles under the onslaught of cholera spirilla, or of dysentery and typhoid bacilli. Huge areas have bee devastated by the trypanosome that travels on the wings of the tsetse fly, and generations have been harassed by the syphilis of a courtier. War and conquest and that herd existence which is an accompaniment of what we call civilization have merely set the stage for these more powerful agents of human tragedy.”

“Don’t try to visualize the great mass audience. There is no such audience—every reader is a different person.”

“Clutter is the disease of American writing. We are a society strangling in unnecessary words, circular constructions, pompous frills and meaningless jargon.”

“Political realism refuses to identify the moral aspirations of a particular nation with the moral laws that govern the universe. As it distinguishes between truth and opinion, so it distinguishes between truth and idolatry. All nations are tempted — and few have been able to resist the power for long — to clothe their own aspirations and action in the moral purposes of the universe. To know that nations are subject to the moral law is one thing, while to pretend to know with certainty what is good and evil in the relations among nations is quite another. There is a world of difference between the belief that all nations stand under the judgment of God, inscrutable to the human mind, and the blasphemous conviction that God is always on one's side and that what one wills oneself cannot fail to be willed by God also.The lighthearted equation between a particular nationalism and the counsels of Providence is morally indefensible, for it is that very sin of pride against which the Greek tragedians and the Biblical prophets have warned rulers and ruled. That equation is also politically pernicious, for it is liable to engender the distortion in judgment which, in the blindness of crusading frenzy, destroys nations and civilizations - in the name of moral principle, ideal, or God himself.”

“People say 'Hofmann has different styles'. I have not. I have different moods; I am not two days the same man.”

“Write about small, self-contained incidents that are still vivid in your memory. If you remember them, it's because they contain a larger truth that your readers will recognize in their own lives. Think small and you'll wind up finding the big themes in your family saga. ”