“I once read that if the folds in the cerebral cortex were smoothed out it would cover a card table. That seemed quite unbelievable but it did make me wonder just how big the cortex would be if you ironed it out. I thought it might just about cover a family-sized pizza: not bad, but no card-table. I was astonished to realize that nobody seems to know the answer. A quick search yielded the following estimates for the smoothed out dimensions of the cerebral cortex of the human brain.An article in Bioscience in November 1987 by Julie Ann Miller claimed the cortex was a "quarter-metre square." That is napkin-sized, about ten inches by ten inches. Scientific American magazine in September 1992 upped the ante considerably with an estimated of 1 1/2 square metres; thats a square of brain forty inches on each side, getting close to the card-table estimate. A psychologist at the University of Toronto figured it would cover the floor of his living room (I haven't seen his living room), but the prize winning estimate so far is from the British magazine New Scientist's poster of the brain published in 1993 which claimed that the cerebral cortex, if flattened out, would cover a tennis court. How can there be such disagreement? How can so many experts not know how big the cortex is? I don't know, but I'm on the hunt for an expert who will say the cortex, when fully spread out, will cover a football field. A Canadian football field.”

“How do we regulate our emotions? The answer is surprisingly simple: by thinking about them. The prefrontal cortex allows each of us to contemplate his or her own mind, a talent psychologists call metacognition. We know when we are angry; every emotional state comes with self-awareness attached, so that an individual can try to figure out why he's feeling what he's feeling. If the particular feeling makes no sense—if the amygdala is simply responding to a loss frame, for example—then it can be discounted. The prefrontal cortex can deliberately choose to ignore the emotional brain.”

“We live in the Age of the Higher Brain, the cerebral cortex that has grown enormously over the last few millennia, overshadowing the ancient, instinctive lower brain. The cortex is often called the new brain, yet the old brain held sway in humans for millions of years, as it does today in most living things. The old brain can’t conjure up ideas or read. But it does possess the power to feel and, above all, to be. It was the old brain that caused our forebears to sense the closeness of a mysterious presence everywhere in Nature.”

“The minds of others are stranger depths to employ our hearts to than our own wonderland of cerebral cortex.”

“Judging by your face, the what-the-fuck nodes in your cerebral cortex must be a real light show.”

“For the first time in longer than I can remember, I feel peaceful. Not happy. Not sad. Not anxious. Not horny. Just all the higher parts of my brain closing up shop. The cerebral cortex. The cerebellum. That's where my problem is. I'm now simplifying myself. Somewhere balanced in the perfect middle between happiness and sadness. Because sponges never have a bad day.”

“Let me tell you, though: being the smartest boy in the world wasn’t easy. I didn’t ask for this. I didn’t want this. On the contrary, it was a huge burden. First, there was the task of keeping my brain perfectly protected. My cerebral cortex was a national treasure, a masterpiece of the Sistine Chapel of brains. This was not something that could be treated frivolously. If I could have locked it in a safe, I would have. Instead, I became obsessed with brain damage.”