“One thing I learned, between addiction and depression? Depression a lot worse. Depression ain't something you just get off of. You can't get clean from depression. Depression be like a bruise that never goes away. A bruise in your mind. You just got to be careful not to touch where it hurts. It always be there, though.Darlene, in The Marriage Plot”

“...between addiction and depression? Depression a lot worse. Depression ain't something you just get OFF of. You can't get CLEAN from depression. Depression be like a bruise that never goes away. A bruise in your MIND. You just got to be careful not to touch where it hurts. It always be there, though.”

“Depression is like a bruise that never goes away. A bruise in your mind. You just got to be careful not to touch it where it hurts. It's always there, though.”

“They thought depression was like bieng 'depressed'. They thought it was like being in a bad mood, only worse. Therefore, they tried to get him to snap out of it.”

“That was when Leonard realized something crucial about depression. The smarter you were, the worse it was. The sharper your brain, the more it cut you up.”

“But this was the thought of a depressive. An aspiring depressive, at the time. That was the odd thing about Leonard’s disease, the almost pleasurable way it began. At first his dark moods were closer to melancholy than to despair. There was something enjoyable about wandering around the city alone, feeling forlorn. There was even a sense of superiority, of being right, in not liking the things other kids liked.”

“...that manic depression, far from being a liability was an advantage. It was a selected trait. If it wasn't selected for, then the "disorder" would have disappeared long ago, bred out of the population like anything else that didn't increase the odds of survival. The advantage was obvious. The advantage was the energy, the creativity, the feeling of genius, almost, that Leonard felt right now. There was no telling how many great historical figures had been manic-depressives, how many scientific and artistic breakthroughs had occurred to people during manic episodes.”