“...that manic depression, far from being a liability was an advantage. It was a selected trait. If it wasn't selected for, then the "disorder" would have disappeared long ago, bred out of the population like anything else that didn't increase the odds of survival. The advantage was obvious. The advantage was the energy, the creativity, the feeling of genius, almost, that Leonard felt right now. There was no telling how many great historical figures had been manic-depressives, how many scientific and artistic breakthroughs had occurred to people during manic episodes.”

“But this was the thought of a depressive. An aspiring depressive, at the time. That was the odd thing about Leonard’s disease, the almost pleasurable way it began. At first his dark moods were closer to melancholy than to despair. There was something enjoyable about wandering around the city alone, feeling forlorn. There was even a sense of superiority, of being right, in not liking the things other kids liked.”

“They thought depression was like bieng 'depressed'. They thought it was like being in a bad mood, only worse. Therefore, they tried to get him to snap out of it.”

“...the novel had reached its apogee with the marriage plot and had never recovered from its disappearance. In the days when success in life had depended on marriage, and marriage had depended on money, novelists had had a subject to write about. The great epics sang of war, the novel of marriage. Sexual equality, good for women, had been bad for the novel. And divorce had undone it completely. What would it matter whom Emma married if she could file for separation later? How would Isabel Archer’s marriage to Gilbert Osmond have been affected by the existence of a prenup? As far as Saunders was concerned, marriage didn’t mean much anymore, and neither did the novel. Where could you find the marriage plot nowadays? You couldn’t. You had to read historical fiction. You had to read non-Western novels involving traditional societies. Afghani novels, Indian novels. You had to go, literarily speaking, back in time.”

“The more she thought about it, the more Madeleine understood that extreme solitude didn't just describe the way she was feeling about Leonard. It explained how she'd always felt when she was in love. It explained what love was like and, just maybe, what was wrong with it.”

“That was when Leonard realized something crucial about depression. The smarter you were, the worse it was. The sharper your brain, the more it cut you up.”

“...between addiction and depression? Depression a lot worse. Depression ain't something you just get OFF of. You can't get CLEAN from depression. Depression be like a bruise that never goes away. A bruise in your MIND. You just got to be careful not to touch where it hurts. It always be there, though.”