“This was a characteroloical prelude, but it wasn’t chemical or somatic. It was the anatomy of melancholy, not the anatomy of his brain.”

“But this was the thought of a depressive. An aspiring depressive, at the time. That was the odd thing about Leonard’s disease, the almost pleasurable way it began. At first his dark moods were closer to melancholy than to despair. There was something enjoyable about wandering around the city alone, feeling forlorn. There was even a sense of superiority, of being right, in not liking the things other kids liked.”

“In the end he became as fragmentary as the poems of Sappho he never succeeded in restoring, and finally one morning he looked up into the face of the woman who’d been the greatest love of his life and failed to recognize her. And then there was another kind of blow inside his head; blood pooled in his brain for the last time, washing even the last fragments of his self away.”

“Biology gives you a brain. Life turns it into a mind.”

“Whereas my grandfather was getting used to a much more terrifying reality. Holding my hand to keep his balance, as trees and bushes made strange, sliding movements in his peripheral vision, Lefty was confronting the possibility that consciousness was a biological accident. Though he'd never been religious, he realized now that he'd always believed in the soul, in a force of personality that survived death. But as his mind continued to waver, to short-circuit, he finally arrived at the cold-eyed conclusion, so at odds with his youthful cheerfulness, that the brain was just an organ like any other and that when it failed he would be no more.”

“That was when Leonard realized something crucial about depression. The smarter you were, the worse it was. The sharper your brain, the more it cut you up.”

“Depending on the year or the therapist he was seeing, he'd learned to ascribe just about every facet of his character as a psychological reaction to his parents' fighting: his laziness, his overachieving, his tendency to isolate, his tendency to seduce, his hypochondria, his sense of invulnerability, his self-loathing, his narcissism.”