“One of the difficulties I experienced in trying to learn about the biology of emotions was the definition of terms...How would [Prof. Richard Davidson], as an experimental psychologist, deconstruct [hope]? "I understand hope as an emotion made up of two parts: a cognitive part and an affective part. When we hope for something, we employ, to some degree, our cognition, marshalling information and data relevant to a desired future event. If...you are suffering with a serious illness and you hope for improvement, even for a cure, you have to generate a different vision of your condition in your mind. That picture is painted in part by assimilating information about the disease and its potential treatments. "But hope also involves what I would call affective forecasting--that is, the comforting, energizing, elevating feeling that you experience when you project in your mind a positive future. This requires the brain to generate a different affective, or feeling, state than the one you are currently in.”

“No one should be surprised at the difficulty of faith, if there is some part of his life where he is consciously resisting or disobeying the commandment of Jesus. Is there some part of your life which you are refusing to surrender at his behest, some sinful passion, maybe, or some animosity, some hope, perhaps your ambition or your reason? ... How can you hope to enter into communion with him when at some point in your life you are running away from him?”

“If you are reading this book and you feel that way too then you are not alone. I understand how you feel. I think that anyone who has suffered from even mild depression understands how it feels. Yet we forget that others understand our suffering. We withdraw, isolate or shut down completely. We lose ourselves in our selves, and in the illness.It doesn’t have to be that way. If we connect with even one other human being who understands, we take one step out of the illness. Life is about connection. There is nothing else. Depression is the opposite; it is an illness defined by alienation. So I offer this book by way of connection. I offer it, too, as a source of hope. I hope that by sharing what I was like, what happened and what I am like now, that it may bring someone else comfort.”

“Imagine how different dialogue might be with future generations raised on the idea that there are biological constraints on our ability to know what we know. To me, that is our only hope.”

“As for you, Man, you will be a naked tool all your life, though a user of tools. You will look like an embryo till they bury you, but all the others will be embryos before your might. Eternally undeveloped, you will always remain potential in Our image, able to see some of Our sorrows and to feel some of Our joys. We are partly sorry for you, Man, but partly hopeful. Run along then, and do your best.”

“how much have i changed. i was a parent-pleaser, a dutiful friend. i made safe, careful choices and hoped that things would fall into place for me. but i have learned that you make your own happiness, that part of going for what you want means losing something else. and when the stakes are high, the losses can be that much greater”