“Depression is the most unpleasant thing I have ever experienced. . . . It is that absence of being able to envisage that you will ever be cheerful again. The absence of hope. That very deadened feeling, which is so very different from feeling sad. Sad hurts but it's a healthy feeling. It is a necessary thing to feel. Depression is very different.”

“That’s the thing I want to make clear about depression: It’s got nothing at all to do with life. In the course of life, there is sadness and pain and sorror, all of which, in their right time and season, are normal—unpleasant, but normal. Depression is an altogether different zone because it involves a complete absence: absence of affect, absence of feeling, absence of response, absence of interest. The pain you feel in the course of a major clinical depression is an attempt on nature’s part (nature, after all, abhors a vacuum) to fill up the empty space. But for all intents and purposes, the deeply depressed are just the walking, waking dead.”

“It’s so difficult to describe depression to someone who’s never been there, because it’s not sadness. I know sadness. Sadness is to cry and to feel. But it’s that cold absence of feeling— that really hollowed-out feeling.”

“It’s not only about sadness. In truth, sadness really has little to do with it. Depression is pain in its purest form and I would do anything to be able to feel an emotion again. Any emotion at all. Pain hurts, but pain that’s so powerful that you can’t feel anything anymore, that’s when you start to feel like you’re going crazy.”

“Depression isn't just being a bit sad. It's feeling nothing. It's not wanting to be alive anymore.”

“I think you ought to know I'm feeling very depressed.”