“I saw, during the midterm campaign of 2006, how difficult it was for opponents of stem cell research to run against hope. And so it was in the 2008 presidential contest. This was hope in the collective, a definition that should always apply to the expression of a people's political will. Christopher Reeve had believed in a formula: optimism + information = hope. In this case, the informing agent was us. Granted, it may all look different in six months to a year, but it is hard not to be buoyed by the desire for positive change as articulated and advanced by Barack Obama. It is okay to hope. This time the aspiration of many will not be derided as desperation by a few, as it was during the stem cell debate of '06.By the time you read this book, President Obama and the 111th Congress will have established federal funding for stem cell research. The dam has broken.Just as I'd hoped.”

“Chris[topher] Reeve wisely parsed the difference between optimism and hope. Unlike optimism, he said, 'Hope is the product of knowledge and the projection of where the knowledge can take us.”

“She doesn't know I cry for the changing times. That just as I reread favourite books, some small part of me hoping for a different ending, I find myself hoping against hope that the war will never come. That this time, somehow, it will leave us be.”

“The stakes involved in Washington policy debates are often so high-- whether we send our young men and women to war; whether we allow stem cell research to go forward-- that even small differences in perspective are magnified. The demands of party loyalty, the imperative of campaigns, and the amplification of conflict by the media all contribute to an atmosphere of suspicion. Moreover, most people who serve in Washington have been trained either as lawyers or as political operatives-- professions that tend to place a premium on winning arguments rather than solving problems. I can see how, after a certain amount of time in the capital, it becomes tempting to assume that those who disagree with you have fundamentally different values-- indeed, that they are motivated by bad faith, and perhaps are bad people.”

“The future is not Big Government. Self-serving politicians. Powerful bureaucrats. This has been tried, tested throughout history. The result has always been disaster. President Obama, your agenda is not new. It's not change, and it's not hope.”

“Hope?” he says. “There is always hope, John. New developments have yet to present themselves. Not all the information is in. No. Don’t give up hope just yet. It’s the last thing to go. When you have lost hope, you have lost everything. And when you think all is lost, when all is dire and bleak, there is always hope.”