“Down there between our legs, it's like an entertainment complex in the middle of a sewage system. Who designed that?”

“While the Copernican principle comes with no guarantees that it will forever guide us to cosmic truths, it's worked quite well so far: not only is Earth not in the center of the solar system, but the solar system is not in the center of the Milky Way galaxy, the Milky Way galaxy is not in the center of the universe, and it may come to pass that our universe is just one of many that comprise a multiverse. And in case you're one of those people who thinks that the edge may be a special place, we are not at the edge of anything either.”

“Like the microscopic strands of DNA that predetermine the identity of a macroscopic species and the unique propertires of its members, the modern look and feel of the cosmos was writ in the fabric of its earliest moments, and carried relentlessly through time and space. We feel it when we look up. We feel it when we look down. We feel it when we look within.”

“We spend the first year of a child's life teaching it to walk and talk and the rest of its life to shut up and sit down. There's something wrong there.”

“... informed ignorance provides the natural state of mind for research scientists at the ever-shifting frontiers of knowledge. People who believe themselves ignorant of nothing have neither looked for, nor stumbled upon, the boundary between what is known and unknown in the cosmos.”

“Robots are important also. If I don my pure-scientist hat, I would say just send robots; I'll stay down here and get the data. But nobody's ever given a parade for a robot. Nobody's ever named a high school after a robot. So when I don my public-educator hat, I have to recognize the elements of exploration that excite people. It's not only the discoveries and the beautiful photos that come down from the heavens; it's the vicarious participation in discovery itself.”

“Allow intelligent design into science textbooks, lecture halls, and laboratories, and the cost to the frontier of scientific discovery—the frontier that drives the economies of the future—would be incalculable. I don't want students who could make the next major breakthrough in renewable energy sources or space travel to have been taught that anything they don't understand, and that nobody yet understands, is divinely constructed and therefore beyond their intellectual capacity. The day that happens, Americans will just sit in awe of what we don't understand, while we watch the rest of the world boldly go where no mortal has gone before.”