“I have always been told that a person has to accept that the illness is chronic," she says, at the end of our interview. "You can be 'in recovery,' but you can never be 'recovered.' But I don't want to be on disability forever, and I have started to question whether depression is really a chemical thing. What are the origins of my despair? How can I really help myself? I want to honor the other parts of me, other than the sick part that I'm always thinking about. I think that depression is like a weed that I have been watering, and I want to pull up that weed, and I am starting to look to people for solutions. I really don't know what the drugs did for me all these years, but I do know that I am disappointed in how things have turned out."Such is Melissa Sances's story. Today it is a fairly common one. A distressed teenager is diagnosed with depression and put on an antidepressant, and years later he or she is still struggling with the condition. But if we return to the 1950s, we will discover that the depression rarely struck someone as young as Melissa, and it rarely turned into the chronic suffering that she has experienced. Her course of illness is, for the most part, unique to our times.”

“You don't seem mad at all,' she said.But I am, although I'm undergoing a cure, because my problem is that I lack a particular chemical. However, while I hope that the chemical gets rid of my chronic depression, I want to continue being mad, living life the way I dream it, and not the way other people want it to be. Do you know what exists out there, beyond the walls of Villete?”

“This story ["The Depressed Person"] was the most painful thing I ever wrote. It's about narcissism, which is a part of depression. The character has traits of myself. I really lost friends while writing on that story, I became ugly and unhappy and just yelled at people. The cruel thing with depression is that it's such a self-centered illness - Dostoevsky shows that pretty good in his "Notes from Underground". The depression is painful, you're sapped/consumed by yourself; the worse the depression, the more you just think about yourself and the stranger and repellent you appear to others.”

“I am part of what she thinks is her illness, a symptom of which she thinks she has been cured. She, on the other hand, is what I was looking for.”

“I'm writing this down, because it is going to be hard for me to say it. Because this is probably our last time just us. See, I can write that down, but I don't think I can say it. I'm not doing this to say goodbye, though I know that has to be part of it. I'm doing it to thank you for all we have had and done and been for one another, to say I love you for making this life of mine what it is. Leaving you is the hardest thing I have to do. But the thing is, the best parts of me are in you, all three of you. You are who I am, and what I cherish in myself stays on in you.”

“I am astonished, disappointed, pleased with myself. I am distressed, depressed, rapturous. I am all these things at once, and cannot add up the sum. I am incapable of determining ultimate worth or worthlessness; I have no judgment about myself and my life. There is nothing I am quite sure about. I have no definite convictions - not about anything, really. I know only that I was born and exist, and it seems to me that I have been carried along. I exist on the foundation or something I do not know.”