“I have always been told that a person has to accept that the illness is chronic," she says, at the end of our interview. "You can be 'in recovery,' but you can never be 'recovered.' But I don't want to be on disability forever, and I have started to question whether depression is really a chemical thing. What are the origins of my despair? How can I really help myself? I want to honor the other parts of me, other than the sick part that I'm always thinking about. I think that depression is like a weed that I have been watering, and I want to pull up that weed, and I am starting to look to people for solutions. I really don't know what the drugs did for me all these years, but I do know that I am disappointed in how things have turned out."Such is Melissa Sances's story. Today it is a fairly common one. A distressed teenager is diagnosed with depression and put on an antidepressant, and years later he or she is still struggling with the condition. But if we return to the 1950s, we will discover that the depression rarely struck someone as young as Melissa, and it rarely turned into the chronic suffering that she has experienced. Her course of illness is, for the most part, unique to our times.”

“The cocktail she took usually included a mood stabilizer, an antidepressant, and a benzodiazepine for anxiety, although the exact combination was always changing. One drug would make her sleepy, another would give her tremors, and none of the cocktails seemed to bring her emotional tranquility. Then, in 2001, she was put on an anti-psychotic, Zyprexa, which, in a sense, worked like a charm. "You know what?" she says today, amazed by what she is about to confess. "I loved the stuff. I felt like I finally found the answer. Because what do you know. I have no emotions. It was great. I wasn't crying anymore.”

“You don't seem mad at all,' she said.But I am, although I'm undergoing a cure, because my problem is that I lack a particular chemical. However, while I hope that the chemical gets rid of my chronic depression, I want to continue being mad, living life the way I dream it, and not the way other people want it to be. Do you know what exists out there, beyond the walls of Villete?”

“This story ["The Depressed Person"] was the most painful thing I ever wrote. It's about narcissism, which is a part of depression. The character has traits of myself. I really lost friends while writing on that story, I became ugly and unhappy and just yelled at people. The cruel thing with depression is that it's such a self-centered illness - Dostoevsky shows that pretty good in his "Notes from Underground". The depression is painful, you're sapped/consumed by yourself; the worse the depression, the more you just think about yourself and the stranger and repellent you appear to others.”

“Klonopin ruined my lie. It takes away your drive, and in the morning, you don't want to get out of bed, because you feel so groggy. I don't even know what it's like to feel normal. This is my world. Things don't get me as excited as most people because I'm in a constant state of sedation. It should never have been prescribed for long-term use.”

“I am part of what she thinks is her illness, a symptom of which she thinks she has been cured. She, on the other hand, is what I was looking for.”

“...and she no longer is having her emotional responses to...stress numbed by medication. "I've been off the drugs for two years, and sometimes I find it very, very difficult to deal with my emotions. I tend to have these rages of anger. Did the drugs bring such a cloud over my mind, make me so comatose, that I never gained skills on how to deal with my emotions? Now I'm finding myself getting angrier than ever and getting happier than ever too. The circle with my emotions is getting wider. And yes, it's easy to deal with when you're happy, but how do you deal with it when you're mad? I'm working on not getting overly defensive, and trying to take things in stride.”