“The off-drug patients also suffered less from depression, blunted emotions, and retarded movements. Indeed, they told Carpenter and McGlashan that they had found it "gratifying and informative" to have gone through their psychotic episodes without having their feelings numbed by the drugs. Medicated patients didn't have that same learning experience, and as a result Carpenter and McGlashan concluded, over the long term they "are less able to cope with subsequent life stresses.”

“...and she no longer is having her emotional responses to...stress numbed by medication. "I've been off the drugs for two years, and sometimes I find it very, very difficult to deal with my emotions. I tend to have these rages of anger. Did the drugs bring such a cloud over my mind, make me so comatose, that I never gained skills on how to deal with my emotions? Now I'm finding myself getting angrier than ever and getting happier than ever too. The circle with my emotions is getting wider. And yes, it's easy to deal with when you're happy, but how do you deal with it when you're mad? I'm working on not getting overly defensive, and trying to take things in stride.”

“And what science had revealed was this: Prior to treatment, patients diagnosed with schizophrenia, depression, and other psychiatric disorders do not suffer from any known "chemical imbalance". However, once a person is put on a psychiatric medication, which, in one manner or another, throws a wrench into the usual mechanics of a neuronal pathway, his or her brain begins to function, as Hyman observed, abnormally.”

“The cocktail she took usually included a mood stabilizer, an antidepressant, and a benzodiazepine for anxiety, although the exact combination was always changing. One drug would make her sleepy, another would give her tremors, and none of the cocktails seemed to bring her emotional tranquility. Then, in 2001, she was put on an anti-psychotic, Zyprexa, which, in a sense, worked like a charm. "You know what?" she says today, amazed by what she is about to confess. "I loved the stuff. I felt like I finally found the answer. Because what do you know. I have no emotions. It was great. I wasn't crying anymore.”

“That experience allowed me to see this therapeutic principle in action," Stanton said. "You just can't organize yourself without a connection to another human being, and you can't make that connection if you embalm yourself with drugs.”

“I have always been told that a person has to accept that the illness is chronic," she says, at the end of our interview. "You can be 'in recovery,' but you can never be 'recovered.' But I don't want to be on disability forever, and I have started to question whether depression is really a chemical thing. What are the origins of my despair? How can I really help myself? I want to honor the other parts of me, other than the sick part that I'm always thinking about. I think that depression is like a weed that I have been watering, and I want to pull up that weed, and I am starting to look to people for solutions. I really don't know what the drugs did for me all these years, but I do know that I am disappointed in how things have turned out."Such is Melissa Sances's story. Today it is a fairly common one. A distressed teenager is diagnosed with depression and put on an antidepressant, and years later he or she is still struggling with the condition. But if we return to the 1950s, we will discover that the depression rarely struck someone as young as Melissa, and it rarely turned into the chronic suffering that she has experienced. Her course of illness is, for the most part, unique to our times.”

“Prior to being medicated, a depressed person has no known chemical imbalance.”