“I am diagnosed with not having enough insanely-addictive drugs coursing through my body.”

“But I think you can make fun of anything as long as it's funny enough.”

“If women could ejaculate, I would have exploded hot jizz all over my manager's face. Instead, I hugged him. (about getting the SNL gig as a writer)”

“And there is one thing that I really, really like to have company for. Watching TV. I'm not particularly needy in relationships, I actually demand a fair amount of space. But I really like to be in bed with another human being and watch TV. That's as intimate and reassuring and tender as it gets for me. I find dating exhausting and uninteresting, and I really would like to skip over the hours of conversation that you need just to get up to speed on each other's lives, and the stories I've told a million times. I just want to get to the watching TV in bed. If you're on a date with me, you can be certain that this is what I'm evaluating you for—how good is it going to be, cuddling with you in bed and watching DamagesI'm also looking to see if you have clean teeth. For me, anything less than very clean teeth is fucking disgusting. Here's what I would like to do: I would like to get into bed with a DVD of Damages and have a line of men cue up at my door. I would station a dental hygienist at the front of the line who would examine the men's teeth. Upon passing inspection, she(I've never met a male hygienist, and neither have you) would send them back to my bedroom, one at time, in intervals of ten minutes, during which I would cuddle with the man and watch Damages. Leaving nothing to chance, using some sort of medical telemetry, I would have a clinician take basic readings of my heart rate and brain waves, and create a comparison chart to illustrate which candidate was the most soothing presence for me. After reviewing all the data from what will now be known in diagnostic manuals throughout the world as the Silverman-Damages-Nuzzle-Test, I will make my selection.”

“It seems to me that sometimes the worst parents make the best grandparents. I'm not sure why. Maybe because there is enough of a generational separation that they don't see their grandchildren as an extension of themselves, so their relationship isn't tainted by any self-loathing. And of course, just growing older seems to soften and relax people. Since so many people these days don't seem to start their families until around age forty, I predict there will be less child beating, but more slipped disks from lifting babies out of cribs. Even the father of advanced age who's not inclined to spare the rod is likely to suffer more than his victim: The first punch he throws might well be the last straw for his rotator cuff, reducing his disciplinary options to mere verbal abuse and napping. I'm excited about the next generation!”

“My stepfather, John O'Hara, was the goodest man there was. He was not a man of many words, but of carefully chosen ones. He was the one parent who didn't try to fix me. One night I sat on his lap in his chair by the woodstove, sobbing. He just held me quietly and then asked only, "What does it feel like?" It was the first time I was prompted to articulate it. I thought about it, then said, "I feel homesick." That still feels like the most accurate description - I felt homesick, but I was home.”

“After fifteen years of making my living in stand-up, The Sarah Silverman Program has been a lesson in collaboration. Rob, Dan, and I live by the mantra "Whoever is most passionate." If I was mentoring someone, that's the Shandling-esque advice I would proffer: Find people you really respect and trust, and then at each decision, heed the most passionate voice. I love that because it eliminates nearly all struggle. And when you're doing a show that's mostly about farts, penises, and vaginas, there should be as little struggle as possible.”