“Look, there’s not much useful to take away from this book – it’s largely stories of a woman who has spent her life peeing on herself. But there is one way I really believe I can help the world, and that is to encourage everyone, in all things, to “Make It a Treat”

“The thing about depression is that, if you're not the one who's actually suffering from it, there's very little you can do to be proactive. If someone in your family is depressed, all you can really do is send them to the shrink, get them their meds, be gentle, and wait.”

“And there is one thing that I really, really like to have company for. Watching TV. I'm not particularly needy in relationships, I actually demand a fair amount of space. But I really like to be in bed with another human being and watch TV. That's as intimate and reassuring and tender as it gets for me. I find dating exhausting and uninteresting, and I really would like to skip over the hours of conversation that you need just to get up to speed on each other's lives, and the stories I've told a million times. I just want to get to the watching TV in bed. If you're on a date with me, you can be certain that this is what I'm evaluating you for—how good is it going to be, cuddling with you in bed and watching DamagesI'm also looking to see if you have clean teeth. For me, anything less than very clean teeth is fucking disgusting. Here's what I would like to do: I would like to get into bed with a DVD of Damages and have a line of men cue up at my door. I would station a dental hygienist at the front of the line who would examine the men's teeth. Upon passing inspection, she(I've never met a male hygienist, and neither have you) would send them back to my bedroom, one at time, in intervals of ten minutes, during which I would cuddle with the man and watch Damages. Leaving nothing to chance, using some sort of medical telemetry, I would have a clinician take basic readings of my heart rate and brain waves, and create a comparison chart to illustrate which candidate was the most soothing presence for me. After reviewing all the data from what will now be known in diagnostic manuals throughout the world as the Silverman-Damages-Nuzzle-Test, I will make my selection.”

“At some point, I figured that it would be more effective and far funnier to embrace the ugliest, most terrifying things in the world--the Holocaust, racism, rape, et cetera. But for the sake of comedy, and the comedian's personal sanity, this requires a certain emotional distance. It's akin to being a shrink or a social worker. you might think that the most sensitive, empathetic person would make the best social worker, but that person would end up being soup on the floor. It really takes someone strong--someone, dare I say, with a big fat wall up--to work in a pool of heartbreak all day and not want to fucking kill yourself. But adopting a persona at once ignorant and arrogant allowed me to say what I didn't mean, even preach the opposite of what I believed. For me, it was a funny way to be sincere. And like the jokes in a roast, the hope is that the genuine sentiment--maybe even a goodness underneath the joke (however brutal) transcends.”

“Some people need Hell. If you’re the type of guy who sees a hooker in an alleyway and instinctively thinks, “Hey, now there’s something I could rape and kill without any consequences,” then the concept of Hell might really keep you out of trouble.”

“After fifteen years of making my living in stand-up, The Sarah Silverman Program has been a lesson in collaboration. Rob, Dan, and I live by the mantra "Whoever is most passionate." If I was mentoring someone, that's the Shandling-esque advice I would proffer: Find people you really respect and trust, and then at each decision, heed the most passionate voice. I love that because it eliminates nearly all struggle. And when you're doing a show that's mostly about farts, penises, and vaginas, there should be as little struggle as possible.”

“But I think you can make fun of anything as long as it's funny enough.”