“For years I wondered why dreams are so often dull when related, and this morning I find the answer, which is very simple - like most answers, you have always known it: No context ... like a stuffed animal set on the floor of a bank.”

“You know, they ask me if I were on a desert island and I knew nobody would ever see what I wrote, would I go on writing. My answer is most emphatically yes. I would go on writing for company. Because I'm creating an imaginary — it's always imaginary — world in which I would like to live.(Interview, The Paris Review)”

“Your mind will answer most questions if you learn to relax and wait for the answer.”

“My characters are quite as real to me as so-called real people; which is one reason why I'm not subject to what is known as loneliness. I have plenty of company.”

“The question is frequently asked: Why does a man become a drug addict?The answer is that he usually does not intend to become an addict. You don’t wake up one morning and decide to be a drug addict. It takes at least three months’ shooting twice a day to get any habit at all. And you don’t really know what junk sickness is until you have had several habits. It took me almost six months to get my first habit, and then the withdrawal symptoms were mild. I think it no exaggeration to say it takes about a year and several hundred injections to make an addict.The questions, of course, could be asked: Why did you ever try narcotics? Why did you continue using it long enough to become an addict? You become a narcotics addict because you do not have strong motivations in the other direction. Junk wins by default. I tried it as a matter of curiosity. I drifted along taking shots when I could score. I ended up hooked. Most addicts I have talked to report a similar experience. They did not start using drugs for any reason they can remember. They just drifted along until they got hooked. If you have never been addicted, you can have no clear idea what it means to need junk with the addict’s special need. You don’t decide to be an addict. One morning you wake up sick and you’re an addict. (Junky, Prologue, p. xxxviii)”

“Last night I encountered a dream cat with a very long neck and a body like a human fetus, gray and transluscent. I don't know what it needs or how to provide for it. Another dream years ago of a human child with eyes on stalks. It is very small, but can walk and talk "Don't you want me?" Again, I don't know how to care for the child. But I am dedicated to protecting and nurturing him at any cost! It is the function of the Guardian to protect hybrids and mutants in the vulnerable stage of infancy.”

“America is not so much a nightmare as a non-dream. The American non-dream is precisely a move to wipe the dream out of existence. The dream is a spontaneous happening and therefore dangerous to a control system set up by the non-dreamers.”