“Depression is a disorder of mood, so mysteriously painful and elusive in the way it becomes known to the self -- to the mediating intellect-- as to verge close to being beyond description. It thus remains nearly incomprehensible to those who have not experienced it in its extreme mode.”

“date of the award approached, I would not have accepted at all. Depression is a disorder of mood, so mysteriously painful and elusive in the way it becomes known to the self--to the mediating intellect--as to verge close to being beyond description. It thus remains nearly incomprehensible to those who have not experienced it in its extreme mode, although the gloom, "the blues" which people go through occasionally and associate with the general hassle of everyday existence are of such prevalence that they do give many individuals a hint of the illness in its catastrophic form.”

“Brother, I’m not depressed and haven’t lost spirit. Life everywhere is life, life is in ourselves and not in the external. There will be people near me, and to be a human being among human beings, and remain one forever, no matter what misfortunes befall, not to become depressed, and not to falter – this is what life is, herein lies its task.”

“The horror of profound depression, and the hopelessness that usually accompanies it, are hard to imagine for those who have not experienced them. Because the despair is private, it is resistant to clear and compelling description. Novelist William Styron, however, in recounting his struggle with suicidal depression, captures vividly the heavy, inescapable pain that can lead to suicide: What I had begun to discover is that, mysteriously and in ways that are totally remote from normal experience, the gray drizzle of horror induced by depression takes on the quality of physical pain. But it is not an immediately identifiable pain, like that of a broken limb. It may be more accurate to say that despair, owing to some evil trick played upon the sick brain by the inhabiting psyche, comes to resemble the diabolical discomfort of being imprisoned in a fiercely overheated room. And because no breeze stirs this cauldron, because there is no escape from this smothering confinement, it is entirely natural that the victim begins to think ceaselessly of oblivion.”

“I have an extremely low threshold for disorder; it offends my very being.”

“People who are contented and serene sleep well. They fall asleep easily, stay asleep, and wake refreshed. Conversely, people who are anxious, stressed, or depressed do not sleep well, and chronic insomnia is strongly associated with mood disorders. These are clear correlations, but what is cause and what is effect is not clear. Most experts agree that sleep and mood are closely related, that healthy sleep can enhance emotional well-being, while insufficient quantity or quality of sleep can adversely affect it.”