“I did get a colonic, but I've decided not write about it at length. I didn't find it helpful or enlightening. I can tell you want it felt like, though: It felt like someone shooting water up your butt.”

“I can’t help but notice that you keep writing love poetry to my wife. Well, you see, I married her, which makes her my wife. You know what you might want to try? Writing some poems about the sunset. The sunset isn’t fucking married.”

“I've started to look at life differently. When you're thanking God for every little you - every meal, every time you wake up, every time you take a sip of water - you can't help but be more thankful for life itself, for the unlikely and miraculous fact that you exist at all.”

“I find placebos uplifting and exhilarating. It means that taking action--no matter what the action is--might help you feel better.”

“. . . my obsession with gratefulness. I can't stop. Just now, I press the elevator button and am thankful that it arrives quickly. I get onto the elevator and am thankful that the elevator cable didn't snap and plummet me to the basement. I go to the fifth floor and am thankful that I didn't have to stop on the second or third or fourth floor. I get out and am thankful that Julie left the door unlocked so I don't have to rummage for my King Kong key ring. I walk in, and am thankful that Jasper is home and healthy and stuffing his face with pineapple wedges. And on and on. I'm actually muttering to myself, 'Thank you. . .thank you. . . thank you.' It's an odd way to live. But also kind of great and powerful. I've never before been so aware of the thousands of little good things, the thousands of things that go right every day.”

“If the Britannica has taught me anything, it's to be more careful. I don't want to turn into an unseemly noun or verb or adjective someday. I don't want to be like Charles Boycott, the landlord in Ireland who refused to lower rents during a famine, leading to the original boycott. I don't want to be like Charles Lynch, who headed an irregular court that hung loyalists during the Revolutionary War. I can't have "Jacobs" be a verb that means staying home all the time or washing your hands too frequently.”

“Let me tell you, though: being the smartest boy in the world wasn’t easy. I didn’t ask for this. I didn’t want this. On the contrary, it was a huge burden. First, there was the task of keeping my brain perfectly protected. My cerebral cortex was a national treasure, a masterpiece of the Sistine Chapel of brains. This was not something that could be treated frivolously. If I could have locked it in a safe, I would have. Instead, I became obsessed with brain damage.”