“Will: I read your book last night.Sean: So you're the one.”

“If you think Hollywood is depressing and corrupt, politics is really depressing and corrupt -- and fueled even more than Hollywood by money -- if that's possible.”

“That's you, drops of water and you're on top of the mountain of success. But one day you start sliding down the mountain and you think wait a minute; I'm a mountain top water drop. I don't belong in this valley, this river, this low dark ocean with all these drops of water. Then one day it gets hot and you slowly evaporate into air, way up, higher than any mountain top, all the way to the heavens. Then you understand that it was at your lowest that you were closest to God. Life's a journey that goes round and round and the end is closest to the beginning. So if it's change you need, relish the journey.”

“Books are the key. A book cannot be accessed from afar. You have to hold it, you have to read it.”

“One has the sense of her deciding roughly at Page 2 whether or not a book is worthy; reading the rest of it to gather evidence for her case; spending some quality time with the Thesaurus; and then taking a large blunt hammer and pounding the message home.”

“Shepherd Book: What are we up to, sweetheart? River: Fixing your Bible. Book: I, um... What? River: Bible's broken. Contradictions, false logistics - doesn't make sense. Shepherd Book: No, no. You-you-you can't... River: So we'll integrate non-progressional evolution theory with God's creation of Eden. Eleven inherent metaphoric parallels already there. Eleven. Important number. Prime number. One goes into the house of eleven eleven times, but always comes out one. Noah's ark is a problem. Shepherd Book: Really? River: We'll have to call it early quantum state phenomenon. Only way to fit 5000 species of mammal on the same boat. Shepherd Book: River, you don't fix the Bible. River: It's broken. It doesn't make sense. Book: It's not about making sense. It's about believing in something, and letting that belief be real enough to change your life. It's about faith. You don't fix faith, River. It fixes you.”

“Simon: You're in a dangerous line of work, Jayne. Odds are you'll be under my knife again, often. So I want you to understand one thing very clearly: No matter what you do or say or plot, no matter how you come down on us, I will never, ever harm you. You're on this table, you're safe... 'cause I'm your medic. And however little we may like or trust each other, we're on the same crew. Got the same troubles, same enemies, and more than enough of both. Now, we could circle each other and growl, sleep with one eye open, but that thought wearies me. I don't care what you've done, I don't know what you're planning on doing, but I'm trusting you. I think you should do the same. 'Cause I don't see this working any other way. River: Also, I can kill you with my brain.”