“Flannery O'Connor, in a note to the editor of "Wise Blood" that pertained to changes he wanted to make, wrote "Perhaps I am prematurely arrogant . . .”

“Someone once told the Catholic writer Flannery O’Connor that it is more open-minded to think that the Blessed Sacrament of the Altar is a great, wonderful, powerful symbol. Her response was, “If it’s only a symbol, to hell with it.”

“Wise Blood has reached the age of ten and is still alive. My critical powers are just sufficient to determine this, and I am gratified to be able to say it. The book was written with zest and, if possible, it should be read that way. It is a comic novel about a Christian malgré lui, and as such, very serious, for all comic novels that are any good must be about matters of life and death. Wise Blood was written by an author congenitally innocent of theory, but one with certain preoccupations. That belief in Christ is to some a matter of life and death has been a stumbling block for some readers who would prefer to think it a matter of no great consequence. For them, Hazel Motes's integrity lies in his trying with such vigor to get rid of the ragged figure who moves from tree to tree in the back of his mind. For the author, Hazel's integrity lies in his not being able to do so. Does one's integrity ever lie in what he is not able to do? I think that usually it does, for free will does not mean one will, but many wills conflicting in one man. Freedom cannot be conceived simply. It is a mystery and one which a novel, even a comic novel, can only be asked to deepen.(Preface to second edition, 1962)”

“He said when he went to sell a man a flue, he asked first about that man's wife's health and how his children were. He said he had a book that he kept the names of his customers' families and what was wrong with them. A man's wife had cancer, he put her name down in the book and wrote 'cancer' after it and inquired about her every time he went to that man's hardware store until she died; then he scratched out the word 'cancer' and wrote 'dead' there. "And I say thank God when they're dead," the salesman said; "that's one less to remember.”

“In short, I am amenable to criticism, but only within the sphere of what I am trying to do; I will not pretend to do otherwise.”

“Wise Blood was written by an author congenitally innocent of theory, but one with certain preoccupations. That belief in Christ is to some a matter of life and death has been a stumbling block for readers who would prefer to think it a matter of no great consequence. For them Hazel Motes' integrity lies in his trying with such vigor to get rid of the ragged figure who moves from tree to tree in the back of his mind. For the author Hazel's integrity lies in his not being able to. Does one's integrity ever lie in what he is not able to do? I think that usually it does, for free will does not mean one will, but many wills conflicting in one man. Freedom cannot be conceived simply. It is a mystery and one which a novel, even a comic novel, can only be asked to deepen.”

“Grace changes us and change is painful".”