“I don't think literature would be possible in a determined world. We might go through the motions but the heart would be out of it. Nobody could then 'smile darkly and ignore the howls.' Even if there were no Church to teach me this, writing two novels would do it. I think the more you write, the less inclined you will be to rely on theories like determinism. Mystery isn't something that is gradually evaporating. It grows along with knowledge.”

“The park was the heart of the city. He had come to the city – and with a knowing in his blood – he had established himself at the heart of it. Everyday he looked at the heart of it; every day; he was so stunned and awed and overwhelmed that just to think about it made him sweat. There was something, in the center of the park, that he had discovered. It was a mystery although it was in a glass case for everybody to see and there was a typewritten card over it telling all about it. But there was something the card couldn't say and what it couldn't say was inside him. He could not show the mystery to just anybody; but he had to show it to somebody. Who he had to show it to was a special person. This person could not be from the city but he didn't know why. He knew he would know him when he saw him and that he would have to see him soon or the nerve inside him would grow so big that he would be forced to steal a car or rob a bank or jump out of a dark alley onto a woman.”

“One of the awful things about writing when you are a Christian is that for you the ultimate reality is the Incarnation, the present reality is the Incarnation, and nobody believes in the Incarnation; that is, nobody in your audience. My audience are the people who think God is dead. At least these are the people I am conscious of writing for.”

“Wise Blood has reached the age of ten and is still alive. My critical powers are just sufficient to determine this, and I am gratified to be able to say it. The book was written with zest and, if possible, it should be read that way. It is a comic novel about a Christian malgré lui, and as such, very serious, for all comic novels that are any good must be about matters of life and death. Wise Blood was written by an author congenitally innocent of theory, but one with certain preoccupations. That belief in Christ is to some a matter of life and death has been a stumbling block for some readers who would prefer to think it a matter of no great consequence. For them, Hazel Motes's integrity lies in his trying with such vigor to get rid of the ragged figure who moves from tree to tree in the back of his mind. For the author, Hazel's integrity lies in his not being able to do so. Does one's integrity ever lie in what he is not able to do? I think that usually it does, for free will does not mean one will, but many wills conflicting in one man. Freedom cannot be conceived simply. It is a mystery and one which a novel, even a comic novel, can only be asked to deepen.(Preface to second edition, 1962)”

“People without hope not only don't write novels, but what is more to the point, they don't read them.”

“...I have to write to discover what I am doing. Like the old lady, I don't know so well what I think until I see what I say; then I have to say it again.”

“I write because I don't know what I think until I read what I say.”