“No pill can help me deal with the problem of not wanting to take pills; likewise, no amount of psychotherapy alone can prevent my manias and depressions. I need both. It is an odd thing, owing life to pills, one's own quirks and tenacities, and this unique, strange, and ultimately profound relationship called psychotherapy”

“Like antidepressants, a substantial part of the benefit of psychotherapy depends on a placebo effect, or as Moerman calls it, the meaning response. At least part of the improvement that is produced by these treatments is due to the relationship between the therapist and the client and to the client's expectancy of getting better. That is a problem for antidepressant treatment. It is a problem because drugs are supposed to work because of their chemistry, not because of the psychological factors. But it is not a problem for psychotherapy. Psychotherapists are trained to provide a warm and caring environment in which therapeutic change can take place. Their intention is to replace the hopelessness of depression with a sense of hope and faith in the future. These tasks are part of the essence of psychotherapy. The fact that psychotherapy can mobilize the meaning response - and that it can do so without deception - is one of its strengths, no one of its weaknesses. Because hopelessness is a fundamental characteristic of depression, instilling hope is a specific treatment for it it. Invoking the meaning response is essential for the effective treatment of depression, and the best treatments are those that can do this most effectively and that can do without deception.”

“Sometimes, though, I feel that pushing books is a whole lot like pushing medicine. Think of books as pills. I have pills that cure ignorance and pills that cure boredom. I have pills to elevate moods and pills to open people's eyes to the awful truth: uppers and downers as they were. I sell pills to help people find themselves and pills to help them lose themselves when they require escape from the pressures and anxieties of life in a complex society...”

“I had to stop myself from laughing. Who needs help taking a pill?”

“To these people, unhappiness was a condition, an intolerable state of affairs. If pills could help, pills were taken. But pills were not going to change the fundamental problem in the construction. Wanting what you can´t have. Looking for self-worth in the mirror. Layering work on top of work and still wondering why you weren´t satisfied - before working some more.”

“Depression is a serious problem, but drugs are not the answer. In the long run, psychotherapy is both cheaper and more effective, even for very serious levels of depression. Physical exercise and self-help books based on CBT can also be useful, either alone or in combination with therapy. Reducing social and economic inequality would also reduce the incidence of depression.”