“Imagine how different dialogue might be with future generations raised on the idea that there are biological constraints on our ability to know what we know. To me, that is our only hope.”

“If a conservationist has more stathmin, less risk-taking gene, and the pro-drilling advocate has less stathmin, more risk-taking gene, how can the two have a reasonable dialogue?”

“Though not necessarily aware of when we feel purpose and meaning, we are nearly always aware of the sickening feeling when we don't possess them. This isn't an intellectual misapprehension; it is a gut sense of disorientation and a loss of personal direction. Rarely are brute mental effort and self-help pep talks able to rekindle the missing feeling. For most of us, we simply wait patiently, knowing from past experience that the feeling will return in its own sweet time . . . Of particular interest is [Tolstoy's] conclusion as to the inability of science and reason to provide a personal sense of meaning.”

“We love neither God nor our neighbor as we should. Our love in spiritual things is "too defective, in worldly things too excessive, there is a jar in both." We love the world too much; God too little; our neighbor not at all, or for our own ends.”

“[E]very man hath liberty to write, but few ability. Heretofore learning was graced by judicious scholars, but now noble sciences are vilified by base and illiterate scribblers, that either write for vain-glory, need, to get money, or as Parasites to flatter and collogue with some great men, they put out trifles, rubbish and trash. Among so many thousand Authors you shall scarce find one by reading of whom you shall be any whit better, but rather much worse; by which he is rather infected than any way perfected…What a catalogue of new books this year, all his age (I say) have our Frankfurt Marts, our domestic Marts, brought out. Twice a year we stretch out wits out and set them to sale; after great toil we attain nothing…What a glut of books! Who can read them? As already, we shall have a vast Chaos and confusion of Books, we are oppressed with them, our eyes ache with reading, our fingers with turning. For my part I am one of the number—one of the many—I do not deny it...”

“The commonest weakness of our race is our ability to rationalize our most selfish purposes.”

“Melancholy can be overcome only by melancholy.”